Semantic Computing (SC) is Computing based on Semantics (“meaning”, "context", “intention”). It addresses all types of resources including data, document, tool, device, process and people. The scope of SC includes analytics, semantics description languages and integration, interfaces, and applications including biomed, IoT, cloud computing, SDN, wearable computing, context awareness, mobile computing, search engines, question answering, big data, multimedia, and services. The technical program of the Tenth IEEE International Conference on Semantic Computing (ICSC 2016) will include workshops, invited keynotes, paper presentations, panel discussions, demonstrations, and more. Submissions of high-quality papers describing mature results or ongoing work are invited.