In 2012, IEEE Engineering in Medicine and Biology Society (IEEE-EMBS) launched a Special Topic Conference “IEEE-EMBS International Conferences on Biomedical and Health Informatics (BHI)” with more than 330 registered attendees. Building upon the success of BHI’2012 in Shenzhen China, the second BHI’2014 conference is held in Valencia, Spain during June 1st- 4th, 2014 in Hotel Balneario Las Arenas. The overall theme of the conference is “Translating key health challenges with advances in biomedical informatics.” It will cover diverse topics from cutting-edge biomedical and healthcare technology research and development, clinical applications, to biomedical education. The conference program will consist of high-profile plenary/keynote lectures, industry invited speakers, minisymposia, workshops, special sessions, oral and poster sessions, and exhibitions. All papers will be peer reviewed; accepted full-length (4 page) papers will appear in the Conference Proceedings and be indexed by IEEE Xplore. Best papers will be invited to produce an extended version for an special issue of the Journal on Biomedical Health Informatics (J-BHI) Networking is one of the most interesting facets of IEEE BHI 2014 conference we have dedicated part of the program to social events that are going to give you a lot of opportunities to make personal contacts while enjoying the great offer of culture, fun, food and tourist attractions at Valencia.