723 / 2019-05-09 15:48:10
RPW8/HR Repeats Predict NLR-dependent Hybrid Performances
RPW8, NLR, natural variation, autoimmunity, hybrid performance, MLKL, HET-S
摘要录用
Eunyoung Chae / National University of Singapore
Cristina Barragan / Max Planck Institute for Developmental Biology
Detlef Weigel / Max Planck Institute for Developmental Biology
In many plant species, conflicts between divergent elements of the immune system, especially nucleotide-binding oligomerization domain-like receptors (NLR), can lead to hybrid necrosis. Here, we report deleterious allele-specific interactions between an NLR and a non-NLR gene cluster, resulting in not one, but multiple hybrid necrosis cases in Arabidopsis thaliana. The NLR cluster is RESISTANCE TO PERONOSPORA PARASITICA 7 (RPP7), which can confer strain-specific resistance to oomycetes. The non-NLR cluster is RESISTANCE TO POWDERY MILDEW 8 (RPW8) / HOMOLOG OF RPW8 (HR), which can confer broad-spectrum resistance to both fungi and oomycetes. RPW8/HR proteins contain at the N-terminus a potential transmembrane domain, followed by a specific coiled-coil (CC) domain that is similar to a domain found in pore-forming toxins MLKL and HET-S from mammals and fungi. C-terminal to the CC domain is a variable number of 21- or 14-amino acid repeats, reminiscent of regulatory 21-amino acid repeats in fungal HET-S. The number of repeats in different RPW8/HR proteins along with the sequence of a short C-terminal tail predicts their ability to activate immunity in combination with specific RPP7 partners. Whether a larger or smaller number of repeats is more dangerous depends on the specific RPW8/HR autoimmune risk variant.
重要日期
  • 会议日期

    06月16日

    2019

    06月21日

    2019

  • 05月01日 2019

    初稿截稿日期

  • 06月21日 2019

    注册截止日期

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